This trial investigates the impact of lung cancer treatment on physical status, symptoms and quality of life. Furthermore this trial investigates possible underlying causes and consequences of deconditioning.
Preliminary evidence suggests that patients with lung cancer experience a decrease of exercise tolerance and muscle strength during the course of their treatment. The underlying mechanisms and impact of this change has not yet been investigated. In light of this, our trial will prospectively follow a convenience sample of 150 patients with lung cancer who are undergoing treatment. Patients will be assessed before, during and at the end of the treatment (surgery and/or chemotherapy and/or radiotherapy and/or immunotherapy). The aims of the study are to 1. Investigate physical status, before start of treatment in lung cancer patients in comparison with healthy controls (primary outcome). 2. Investigate changes in physical status over the course of treatment in lung cancer patients (primary outcome). 3. Investigate the relationship between changes in physical status with physical activity and symptoms during treatment for lung cancer (secondary outcome). 4. Investigate the relationship between physical status after treatment for lung cancer and comorbidities, hospitalizations and cancer-related and all-cause mortality (exploratory outcome).
Study Type
OBSERVATIONAL
Enrollment
150
Ziekenhuis Oost-Limburg
Genk, Belgium
6MWT
Time frame: Before start of treatment versus 3 months after treatment initiation
1-minute sit to stand test
Time frame: Before start of treatment versus 3 months after treatment initiation
SPPB
Time frame: Before start of treatment versus 3 months after treatment initiation
Handgrip strength
Time frame: Before start of treatment vs. 3 months after treatment initiation
Daily physical activity (self-reported and accelerometer)
Time frame: Before start of treatment vs. during treatment (surgery: during hospitalization; radio: week 2; chemo: beginning of cycle 2 and cycle 4 (each cycle is 3 weeks); immuno: beginning of cycle 2 and cycle 4) vs. 3 months after treatment initiation
Quadriceps strength (isometric and isokinetic)
Time frame: Before start of treatment vs. 3 months after treatment initiation
Respiratory muscle strength (maximal inspiratory and expiratory pressure)
Time frame: Before start of treatment vs. 3 months after treatment initiation
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