The purpose of this study is to examine the efficacy of dose regimen of serratiopeptidase (serodase 5 mg) as a prospective, randomized, parallel, double blind Placebo- controlled study.
A prospective, randomized, parallel, double blind Placebo- controlled study to examine the efficacy of dose regimen of serratiopeptidase (serodase 5 mg) on 112 males and females volunteers in the treatment of inflammation after third molar surgery, comparing drug treatment vs placebo over a period of 20 weeks To assess the dose effectiveness of the dose regimen of Serodase 5 mg; the primary outcomes are trismus and swelling while inflammation is a secondary outcome.the expected duration of participants participation will be around 5 days divided into 4 visits, the time point of the measurment are (0,2,4 and 5 days). The results are expected to assess the improvement of the maximal interincisal distance, reduction of swelling and improvment in the sensation of post-operative pain.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Enrollment
112
Serodase 5mg two tablets three times per day
Placebo two tablets three times per day
Trimus by measuring the interincisal distance
the increase in the interincisal distance will show a positive effect on the Trismus
Time frame: 5 days
Swelling by using The Laskin method
the decrease in swelling will shows a positive effect on swelling based distances at predetermined time points .
Time frame: 5 days
Post-operative pain
pain will be measured using the numerical pain scale from (0-10) after surgery.
Time frame: 5 days
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