Effect of Intraoperative Nefopam on Acute Pain After Remifentanil Based Anesthesia

Hallym University Kangnam Sacred Heart Hospital60 enrolled

Overview

Many anesthesiologists use the Remifentanil for reducing a surgical pain and stabilizing a vital sign. However, this drug induce postoperative hyperalgesia. Nowadays, many studies report that low-dose Ketamine prevents the opioid-induces hyperalgesia. Nefopam,which is non-opioid analgesic, has similar mechanism with Ketamine. It will be helpful for postoperative pain control, and reduce the needs of opioid.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Cholecystitis

Interventions

NefopamDRUG

KetamineDRUG

SalineDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patient who scheduled laparoscopic cholecystectomy under general anesthesia * American Society of Anesthesiologist(ASA) class I or II * adult patient (age 20 - 65) Exclusion Criteria: * patient who has liver disease * patient who has kidney disease * patient who has diabetes mellitus(DM) or heart disease * patient who takes opioid or beta-blocker * patient who has airway disease * patient who has allergy with the drug

Locations (1)

Hallym University Kangnam Sacred Heart Hospita

Seoul, South Korea

RECRUITING

Outcomes

Primary Outcomes

analgesic requirement

Time frame: During 1 hour at PACU

duration of analgesic free

Time frame: During 1 hour at PACU

Secondary Outcomes

analgesic requirement

Time frame: During 8 hours after arriving at ward

Pain on the VAS scale

Time frame: During 1 hour at PACU

Central Contacts

Mi hyun Lee

CONTACT

+82-02-829-5230 md1212@naver.com

Data from ClinicalTrials.gov

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