Phytoestrogen, NO Donors, N-acetyl Cysteine Add Therapy to Clomiphene Citrate to Improve Pregnancy Rate in PCO Patients

Inclusion Criteria: 1. All patients have PCOS. 2. All patients received CC 100 mg/day for 5 days starting from day 5 with successful ovulation as documented by folliculometry and midluteal serum progesterone with no pregnancy achieved. 3. All patients have patent fallopian tubes by Hysterosalpingography. 4. Their husbands have normal semen analysis according to the modified criteria of WHO. 5. All patients have normal serum prolactin and thyroid profile. 6. Any patient having vaginitis was treated before starting induction. Exclusion Criteria: 1. Other causes of infertility than anovulation. 2. Diabetes or other endocrinological disorders. 3. Age \> 40 years. 4. Smoking. 5. Alcohol use. 6. Presence of ovarian cyst \>2cm on the second day of the cycle. 7. Patients who have received gonadotrophins in the preceeding 6 months. 8. Patients who have done unilateral or bilateral ovarian drilling. 9. Allergy to PE, NO donors or NAC