Degradation of the Anorexic Hormone Peptide YY

Early Phase 1CompletedNCT02493959

Hvidovre University Hospital8 enrolled

Overview

Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.

Study Type

INTERVENTIONAL

Allocation

Purpose

BASIC_SCIENCE

Masking

SINGLE

Enrollment

Conditions

Healthy

Interventions

PYY1-36 infusionBIOLOGICAL

Infusion of 1.6 pmol/kg/min PYY1-36 for 2 hrs.

PYY1-36 + sitagliptinBIOLOGICAL

Infusion of 1.6 pmol/kg/min PYY1-36 for 2 hrs. Two doses of 100 mg sitagliptin are administered 10 and 1 hour before start of infusion, respectively.

PYY3-36 infusionBIOLOGICAL

0.8 pmol/kg/min infusion of PYY3-36.

Eligibility

Sex: MALEMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Healthy * Normal BMI (18.5-25kg/m2) Exclusion Criteria: * Diabetes Mellitus * Gastric bypass * Non-caucasian * Height changes \>3 kg within last two months * Hemoglobin \< 7.6 mmol/l * Chronic disease * Smoking * Regularly use of medicine * Drug abuse

Locations (1)

Department of Endocrinology, Hvidovre Hospital

Hvidovre, Denmark

Outcomes

Primary Outcomes

PYY3-34 concentration

Time frame: 0-240 min

Half-lives of PYY1-36 and PYY3-36

Time frame: 0-240 min

Data from ClinicalTrials.gov

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