Coronary Disease and the Effect of High-intensity Interval Training

Norwegian University of Science and Technology60 enrolled

Overview

The primary purpose of this study is to investigate if systematic, high intensity, interval-based aerobic exercise training results in regression of lipid content of atherosclerotic coronary artery plaques, and in reduction of plaque burden in patients with stable coronary heart disease. Composition and morphologic characteristics of plaques will be studied by intra-coronary near-infrared spectroscopy (NIRS) and intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

Conditions

Coronary Disease

Interventions

high intensity interval-based aerobic exerciseBEHAVIORAL

Interval exercises done 3 times weekly during 6 months according to standard procedures at the Department of Circulation and Medical Imaging.

Usual careOTHER

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * stable coronary artery disease * will undergo cardiac catheterization * will be treated with percutaneous coronary intervention (PCI) * signed written informed consent * able to execute the intervention Exclusion Criteria: * earlier bypass surgery * known inflammatory disease other than atherosclerosis * planned surgery within 4 months * included in another randomized controlled study

Locations (1)

St Olavs Hospital

Trondheim, Norway

Outcomes

Primary Outcomes

lipid content of atherosclerotic coronary artery plaques

Lipid core burden index (LCBI) measured by intracoronary near-infrared spectroscopy

Time frame: 6 months

Data from ClinicalTrials.gov

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