Esophageal Atresia: Metaplasia, Barrett

University Hospital, Lille120 enrolled

Overview

The frequency of Barrett's esophagus (BE) has increased in adults in the last decades, but BE is rare in children. Esophageal atresia (EA), the most common congenital anomaly affecting the esophagus, predisposes the patient to severe and prolonged gastroesophageal reflux disease. Because gastroesophageal reflux disease plays a major role in the development of BE by causing repeated mucosal damage, development of BE is a concern even in children and young adults in this specific population. The aim of this study is to assess the prevalence of BE (gastric and/or intestinal metaplasia) in a population of adolescents/young adults who had been treated for EA in early infancy. All eligible patients received upper gastrointestinal endoscopy under general anesthesia with standardized esophageal staged biopsies. Histological suspicion of metaplasia was confirmed centrally.

Study Type

OBSERVATIONAL

Enrollment

120

Conditions

Gastroesophageal Reflux Esophagus, Barrett

Interventions

esophageal biopsies

Eligibility

Sex: ALLMin age: 15 YearsMax age: 19 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Medical history of esophageal atresia (all types, Ladd's classification) Exclusion Criteria: * No medical history of esophageal atresia * Non acceptance to participate from the patient and/or his parents * esophageal atresia treated with esophageal replacement (e.g., coloplasty, gastric transposition)

Locations (20)

Cliniques Universitaires St Luc,

Brussels, Belgium

Department of Pediatric Gastroenterology, AZ VUB,

Brussels, Belgium

Department of Pediatric Gastroenterology, HUDERF,

Brussels, Belgium

Department of Gastroenterology CHC, Liège

Liège, Belgium

Hôpital Mère-Enfants Ste Justine, Montréal, Canada

Montreal, Canada

CHU Angers

Angers, France

CHU, Bordeaux

Bordeaux, France

CHU, Caen

Caen, France

Centre Hospitalier

Le Havre, France

University Hospital, Hôpital Jeanne de Flandres

Lille, France

...and 10 more locations

Outcomes

Primary Outcomes

presence of gastric and / or intestinal metaplasia diagnosed at histology

Prevalence of Barrett's esophagus (gastric and/or intestinal metaplasia) in adolescents treated for esophageal atresia

Time frame: during 2 hours of the endoscopy exam

Secondary Outcomes

presence of esophagitis or anomalies at the anastomotic stage diagnosed at histology

Time frame: during 2 hours of the endoscopy exam

evaluation of the nutritional status

Time frame: during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day)

evaluation of actual symptoms and treatment of gastroesophageal reflux disease

Time frame: during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day)

evaluation of actual other symptoms (respiratory, dysphagia)

Time frame: during the single visit scheduled, the day of endoscopy. This periode is corresponding at a day hospitalization (less than 12 hours in the day)