Patients were recruited at the scheduled preoperative visit for hip or knee arthroplasty. If the haemoglobin (Hb) level was below 13 g/dl with no contraindication to iron supplementation the patients were randomized to the oral or intravenous (IV) group. The oral group received 160 mg ferrous glycine sulfate daily during the month prior surgery, associated with 3 epoetin alpha (EPO) injections (40 000 IU subcutaneous on day - 21, day - 14 and day-7). The IV group received ferric carboxymaltose 1000 mg IV in 15 minutes one month before surgery, associated with 3 EPO injections. Primary efficacy endpoint was the change in Hb level from the day of the preoperative visit to the day before surgery (day-1). Secondary endpoints comprised the Hb level on day 3 and 5 after surgery, allogenic transfusion during and after surgery, and the change in iron indices from the day of the preoperative visit to day - 1.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
SINGLE
Enrollment
100
Hôpital Lapeyronie - Département Anesthésie Réanimation A
Montpellier, France
Compare Hb level after treatment with EPO associated with iron treatment by oral or intravenous route
Time frame: the day before surgery (day - 1)
Hb level
Time frame: before iron treatment, then the day before surgery (day - 1) based on reference iron balance
number of red blood cells
Time frame: during surgery and 3 days after surgery
the change in iron indices
Time frame: before iron treatment and after iron treatment the day before surgery (day - 1)
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