The aim of this study is to identify genetic loci,or gene variations contributing to the development of coronary artery disease (CAD) in Chinese young adults. Investigators will compare coronary angiogram results to genetic findings within young CAD patients.
During last 10 years, the rise in coronary artery disease (CAD) prevalence in Chinese young adults is observed and percutaneous coronary intervention (PCI) is generally considered to be low operative risk in these young patients. Genome-wide association studies have identified a considerable number of common genetic variants related to CAD. However, the extent to which these genetic variants are related to the future cardiovascular events, the prevalence, extent, severity, and prognosis of young patients with CAD is not clear. The aim of this study is to investigate the genetic loci, or gene variations contributing to the development and prognosis of CAD in Chinese young adult. Investigators will compare the angiogram results to genetic findings first in patients with different stages of CAD. Then, investigators will collect patients from hospital discharge registry, and compare long-term outcome as well as on operative details in different gene groups. The results of the study provide a possibility to develop a gene test to recognize patients at risk at its early stage, and needing for preventive medicine.
Study Type
OBSERVATIONAL
Enrollment
2,000
Number of cardiac death
Any death from cardiac conditions
Time frame: 36 months
Number of patients developing myocardial infarction
Any case of acute myocardial infarction which meet the Criteria according to current guidelines.
Time frame: 36 months
Number of patients developing stroke
Any events of ishcemic stroke, TIA or hemorrhagic stroke
Time frame: 36 months
Number of participants undergoing unscheduled repeat revascularization of target or non-target vessel
Any unshceduled percutaneous coronary intervention or coronary artery bypass grafting after primary revascularization
Time frame: 36 months
Number of stent thrombosis, bleeding、non-cardiac death and all-cause death.
Composite of stent thrombosis, bleeding、non-cardiac death and all-cause death.
Time frame: 36 months
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