Acute Effects of Fats on Satiety and Energy Needs

USDA Grand Forks Human Nutrition Research Center23 enrolled

Overview

The purpose of this study is to assess the acute effect of dietary fat on satiety and energy metabolism.

The influences of specific dietary fat sources on satiety, appetite and energy utilization remains unclear; evidence is lacking on whether responses vary according to acute intake. The researchers will use a controlled setting to determine whether the source of dietary fat is related to perceived satiety, satiety hormone responses, and energy expenditure by conducting experiments to evaluate short term (acute) effects.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

OTHER

Masking

QUADRUPLE

Enrollment

Conditions

Obesity

Interventions

SFAOTHER

High saturated fatty acid/SFA oil source

MUFAOTHER

High monounsaturated fatty acid/MUFA oil source

PUFA-LAOTHER

High polyunsaturated fatty acid (linoleic)/PUFA-LA oil source

ALA

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * body mass index between 18.0-34.9 kg/m2 * free of major diagnosed, untreated medical conditions * controlled hypertension * non-smoking or use of other tobacco products, including e-cigarettes * not taking steroid-based medications * not planning to or currently attempting to gain or lose weight * willing to comply with study demands * use of oral contraceptives * low intake of long chain omega 3 fatty acids Exclusion Criteria: * diagnosed eating disorders * diabetes (blood sugar ≥ 126 mg/dl) * hypertension (systolic ≥ 160 mmHg or diastolic \> 100 mmHg) * diagnosed cardiovascular, pulmonary, skeletal and metabolic disease * currently pregnant or planning to become pregnant, or lactating * taking medications known to affect appetite, blood lipids, body composition, body weight, or food intake (appetite control drugs, steroids, antidepressants)

Locations (1)

USDA Grand Forks Human Nutrition Research Center

Grand Forks, North Dakota, United States

Outcomes

Primary Outcomes

Acute effect of fat intake on energy expenditure as determined by metabolic rate

Time frame: Incremental Area Under the Curve (iAUC) of metabolic rate from 0 to 4 hours

Data from ClinicalTrials.gov

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