A Study of the Absorption, Metabolism, and Excretion of GBT440 in Healthy Male Subjects

Inclusion Criteria: 1. Healthy; non-smoking male; 18 to 55 years old, inclusive 2. Weighs at least 50 kg and not more than 110 kg 3. Agrees to use contraception 4. Willing and able to give written informed consent Exclusion Criteria: 1. Evidence or history of clinically significant metabolic, allergic, dermatological, hepatic, renal, hematological, pulmonary, cardiovascular, gastrointestinal, neurological, or psychiatric disorder 2. History of stomach or intestinal surgery that would potentially alter drug absorption 3. History of hypersensitivity or allergy to drugs, foods, or other substances 4. History or presence of abnormal electrocardiogram 5. Exposure to significant radiation or participated in more than 1 other radiolabeled study drug trial within 12 months of Screening 6. Participated in another clinical trial of an investigational drug within 30 days (or 5 half-lives of the investigational drug, whichever is longer) prior to Screening