This is a pilot human experimental study to evaluate whether the use of an e-cigarette affects lung function, exhaled CO levels, and quantitative tobacco cigarette consumption in active tobacco smokers. Subjects recruited from the Winchester Chest Clinic (WCC), Adult Primary Care Clinic (PCC) and the Smilow Cancer Hospital Smoking Cessation Service will be randomized to 1 of 2 groups: (1) nicotine patch and intensive counseling (standard care) plus nicotine e-cigarette; (2) nicotine patch and intensive counseling plus non-nicotine e-cigarette.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Enrollment
40
Patients will receive nicotine patch and intensive counseling plus e-cigarette with nicotine.
Patients will receive nicotine patch and intensive counseling plus e-cigarette without nicotine.
Yale-New Haven Hospital
New Haven, Connecticut, United States
Change in daily quantitative cigarette smoking
Quantitative tobacco cigarette smoking will be measured by experimenter-administered rating scale for 30 days prior to treatment through 6 month follow-up.
Time frame: baseline, 8 weeks, and 6 months.
Change in exhaled carbon monoxide (CO) levels
Exhaled carbon monoxide levels will be measured with a precision instrument for detecting CO in exhaled breath.
Time frame: baseline, 8 weeks, and 6 months.
Short-term impact on lung function (spirometry)
Lung function will be measured by spirometry at time of study enrollment and at 6 months.
Time frame: 6 months
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