A Study to Determine Bioequivalence of Isotretinoin in Healthy Male Subjects Under Fed Condition

Inclusion Criteria: * Included in study will be male volunteers. * Ages between 18 and 45 years old. * BMI (Body Mass Index) between 20 to 26 kilogram/meter square (kg/m\^2). * Anti-doping tests negative results. * Negative test results for Ac human immunodeficiency virus (HIV), HBsAg (hepatitis B surface antigen), and rapid plasma regain (RPR; syphilis test). * Clinical biochemical test values: Hematic Biometry, Urine Analysis, Biochemical Profile: (Glucose, Ureic Nitrogen, Urea, Creatinine, Uric Acid, Cholesterol, Triglycerides, Total Proteins, Albumin, Globulin, Bilirubin (total, indirect and direct), Alkaline Phosphatase (ALP), Lactic Dehydrogenase, Asparate aminotransferase (AST), Alanine aminotransferase (ALT), Calcium, Phosphorus, Sodium, Potassium, Chlorine and Iron), Ac HIV, HBsAg and RPR, must fall within an interval between minimum and maximum values in connection to said tests accepted values. * Normal Electrocardiogram (ECG) and Chest X-rays. * Complete the scale 'Columbia Suicide Severity Rating Scale' (C-SSRS), before and after each dosification period. * Obtain a grade of zero in the C-SSRS. * Signed the Informed Consent corresponding to the bioequivalence study. * In exception cases, accepted may be a candidate for which any previously mentioned test is exceeded regarding considered valid maximum and minimum accepted normal values, as long as it involves an isolated value and there are no other manifestations which could allow assuming that a given value is related to a disease or is remnant of another. These cases must be approved by clinical area and declared as "Non-clinically significant". Exclusion Criteria: * Electrocardiographic Anomalies; radiological * Anti-doping tests positive results, * Positive results regarding RPR; HIV and HBsAg tests. * Personal or family history of allergy to medication in question. * Having any kind of allergy, since these persons are in higher risk of suffering from medication allergy. * Tobacco use. * Persons undergoing any medical treatment. * Existence of concurrent or intercurrent disease. * History psychiatric disorder (eg, Major Depressive Disorder, Generalized Anxiety Disorder, Bipolar Disorder (I or II), or schizophrenia). * Existence of justified doubt regarding questionnaire answers truthfulness. * Having participated in bioequivalence or bioavailability studies or having donated blood 2 months before the study. * Presence of clinically important gastrointestinal diseases or malabsorption history during the last year. * Presence of a medical condition requiring regular medication (with prescription or over-the- counter medication) with systemic absorption. * Drugs or alcohol addiction history requiring treatment. * Refuse to take the scale 'C-SSRS, before and after each dosification period. * Obtain a grade greater than zero in the C-SSRS. * Do not sign the Informed Consent corresponding to the bioequivalence study. * Finally, excluded will be all those volunteers not meeting that established in Mexican Official Standard NOM-177-SSA1-1998.