The investigators aim to evaluate circulating irisin levels alterations in patients with acute myocardial infraction and in patients with coronary artery disease subjected to percutaneous coronary intervention.
Irisin is a newly discovered myokine induced in exercise. There is evidence that cardiac muscle produces more irisin than skeletal muscle in response to exercise. Furthermore, irisin has been associated with isoproterenol-induced myocardial infarction (MI) in rats while it has been reported to decrease after acute myocardial infarction in humans. The investigators aim 1) to investigate circulating irisin levels in patients at the time of acute myocardial infarction and after reprefusion \[primary percutaneous coronary intervention (PCI)\] 2) to compare irisin' s diagnostic and prognostic value and specificity value in myocardial infarction with known markers of cardiac injury such as creatine kinase-MB isoenzyme (CK-MB) and troponin 3) to evaluate irisin as an early necrosis biomarker 4) To evaluate irisin's sensitivity as a biomarker to detect minor myocardial necrosis after elective percutaneous coronary intervention
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
116
a non-surgical procedure used to treat the stenotic (narrowed) coronary arteries of the heart found in coronary heart disease
is a procedure performed along with cardiac catheterization that uses X-ray imaging to see your heart's blood vessels
A stent is placed in an artery as part of a procedure called percutaneous coronary intervention (PCI) to restore blood flow through narrow or blocked arteries. A stent helps support the inner wall of the artery in the months or years after PCI.
424 General Military Hospital
Thessaloniki, Greece
changes from baseline in serum irisin measured by ELISA
Time frame: baseline and 6 hours or 24 hours
changes from baseline in troponin
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum lactate dehydrogenase
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum creatine kinase
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum creatine kinase-MB isoenzyme
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum follistatin
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum follistatin-like protein 3 (FSTL-3)
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum Activin A
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum Activin B
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum insulin growth factor 1 (IGF1)
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum insulin growth factor binding protein 3 (IGFBP3)
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Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum insulin growth factor binding protein 4 (IGFBP4)
Time frame: baseline and 6 hours or 24 hours
changes from baseline in serum pico pregnancy-associated plasma protein A (PAPP-A)
Time frame: baseline and 6 hours or 24 hours