Phase 2a RDEA3170 and Allopurinol Combination Study in Gout Subjects

Inclusion Criteria: * Subject is able to understand the study procedures and the risks involved and is willing to provide written informed consent before the first study-related activity. * Subject meets one or more criteria for the diagnosis of gout as per the American Rheumatism Association Criteria for the Classification of Acute Arthritis of Primary Gout. * Subject has a body weight ≥ 50 kg (110 lbs.) and a body mass index ≥ 18 and ≤ 45 kg/m2. * Subject has a Screening serum urate level ≥ 8 mg/dL. * Subject is free of any clinically significant disease or medical condition, per the Investigator's judgment. Exclusion Criteria: * Subject is unable to take colchicine for gout flare prophylaxis. * Subject has a history or suspicion of kidney stones. * Subject has any gastrointestinal disorder that affects motility and/or absorption. * Subject had unstable angina, New York Heart Association class III or IV heart failure, ischemic heart disease, stroke, or deep venous thrombosis within 12 months prior to Day 1; or subject is currently receiving anticoagulants. * Subject has Screening laboratory parameters that are outside the normal limits and are considered clinically significant by the Investigator. * Subject has an estimated creatinine clearance \< 60 mL/min calculated by the Cockcroft-Gault formula using ideal body weight during the Screening period. * Subject is taking losartan, fenofibrate, guaifenesin, or sodium-glucose linked transporter-2 inhibitors; chronic and stable doses are permitted if doses are stable for at least 14 days prior to study medication dosing. * Subject is unable or unwilling to comply with the study requirements or has a situation or condition that, in the opinion of the Investigator, may interfere with participation in the study.