The Association of SERPINA1 Gene Disturbance in Patients With Lung and Gum Disorders

Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre60 enrolled

Overview

Chronic obstructive pulmonary disease and periodontitis are chronic inflammatory diseases. The study aims to determine if the genetic polymorphism of SERPINA1 gene in patients with COPD serve as a risk factor for developing periodontitis.

periodontitis is a polymicrobial inflammatory disease caused by various modifiable and non-modifiable risk factors. the non-modifiable risk factors include genetic polymorphisms like the gene coding for alpha-1-antitrypsinase COPD is a chronic inflammatory disease characterized by deterioration of lung function due to loss of elasticity of the lungs. SERPINA1 gene product has a protective role on the connective tissue components of both lungs and gums. Hence, this study tries to determine if the gene polymorphism in COPD serves as a risk factor for developing periodontitis.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Pulmonary Disease, Chronic Obstructive Generalized Chronic Periodontitis

Interventions

SERPINA1 geneGENETIC

2ml blood sample collected from patients to extract DNA for assessment of SERPINA1 gene polymorphism

Eligibility

Sex: ALLMin age: 30 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Male and female patients aged between 30-70yrs diagnosed with COPD and chronic periodontitis who are willing to participate in the study. Exclusion Criteria: * Pateints with other systemic disorders * patients not willing to participate in the study

Locations (1)

Dr. Sneha Agarwal PG(periodontics)

Hyderabad, Telangana, India

Outcomes

Primary Outcomes

SERPINA1 gene polymorphism

of blood samples and running samples by PCR

Time frame: 9 months

Data from ClinicalTrials.gov

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