Association Between Mitochondrial DNA Content and Risk of Coronary Heart Disease

Air Force Military Medical University, China400 enrolled

Overview

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of cardiovascular disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood cells could be used as a risk predictor for coronary heart disease.

Study Type

OBSERVATIONAL

Enrollment

400

Conditions

Coronary Heart Disease

Eligibility

Sex: ALLMin age: 18 YearsMax age: 85 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. History of documented myocardial infarction; 2. Prior coronary revascularization intervention (coronary artery bypass graft surgery or percutaneous coronary intervention); 3. The presence of ≥ 50% stenosis in one or more coronary arteries identified during cardiac catheterization; Exclusion Criteria: 1. History of malignancy or end-stage renal disease; 2. Blood transfusion within one month or prior bone marrow transplantation 3. Patients who reluctant to sign informed consent

Locations (1)

Xijing Hospital

Xi'an, Shaanxi, China

Outcomes

Primary Outcomes

Relative copy number of mitochondrial DNA

The ratio of mitochondrial DNA copy number to hemoglobin copy number was calculated for each sample from standard curves. After that, the ratio for each sample was normalized to a calibrator DNA in order to standardize between different runs, and then defined as the measurement of relative mtDNA copy number.Relative copy number of Mitochondrial DNA were measured in CHD patients in comparison to control group.

Time frame: From date of percutaneous coronary intervention until the date of discharging from hospital, assessed up to 5 days

Data from ClinicalTrials.gov

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