The Evaluation of Effect of Sanyinjiao (SP6) Acupressure on Early Diabetic Nephropathy

Inclusion Criteria: 1. age between 20 and 80 years old; 2. HbA1c was lower than 9% according to the NGSP(National Glycohaemoglobin Standardisation Programme); 3. estimated glomerular filtration rate (eGFR) was more than 60 mL/min/1.73 m2. Exclusion Criteria: 1. Hyperglycemic crisis, including HHS(hyperglycemic hyperosmolar syndrome) and DKA(diabetic ketoacidosis ); 2. Persist diabetes poorly control, Hemoglobin A1c \[HbA1c\] \>9%; 3. Endocrine disorders: such as abnormal function of thyroid, pituitary, and sex glands; 4. heart diseases:such as arrhythmia, myocardial infarction, heart failure, or installed pacemaker; 5. immune and allergic diseases: such as systemic lupus erythematosus and asthma; 6. liver or kidney dysfunction: GOT or GPT(glutamate-pyruvate transaminase ) \> 80 IU/L, eGFR\<60 (mL/min); 7. pregnant or lactating women; 8. less than 6months postpartum; 9. acute illness, fever, Lower urinary tract infection, NSAID(nonsteroidal antiinflammatory drug) administration; 10. physical dysfunction because of stroke.