To investigate the effects of different doses of cisatracurium pretreatment on succinylcholine-induced fasciculations.
Ninety patients scheduled for laparoscopic cholecystectomies were equally randomized into three groups to receive pretreatment of 0.005, 0.01, and 0.02 mg/kg cisatracurium, respectively. General anesthesia was induced 3.5 min later, train of four stimulation was monitored 4.5 min later, succinylcholine 1.5 mg/kg was injected 5 min later, and endotracheal intubation was implemented 6.5 min later. The side effects of cisatracurium, intensity of fasciculations, intubating conditions, time and extent to maximal depression of twitch and time for its recovery to 20% of control value, severity of myalgia at 24 h postoperatively, serum potassium before cisatracurium pretreatments, at intubating time, and 5 min after intubation were recorded.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
QUADRUPLE
Enrollment
87
Different groups received different pretreatments of cisatracurium.
Presence of fasciculations
Time frame: After the injection of succinylcholine for 1.5 minutes
Side effects of the pretreatment of cisatracurium
Time frame: From the time of 3 minutes after the pretreatment of cisatracurium for 0.5 minutes
The time to maximal depression of twitch
Time frame: From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes
The extent to maximal depression of twitch
Time frame: From the time of 4.5 minutes after the pretreatment of cisatracurium for two minutes
The grades of endotracheal intubation
Time frame: At intubating time
The changes of serum potassium
Time frame: After entering the operating theater till the anesthesia induction, at intubating, and 5 min after intubation
Myalgia at 24 hours postoperatively
Time frame: At 24 hours postoperatively
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