Musculoskeletal Ultrasound in Asymptomatic Hyperuricemia

Washington D.C. Veterans Affairs Medical Center150 enrolled

Overview

An observational study to evaluate the prevalence of US changes of gout in the joints and tendons of patients with different degrees of asymptomatic hyperuricemia. The investigators' findings may support the extension of the spectrum of urate disease, and define a subset of patients that may benefit from early urate-lowering therapy.

Study Type

OBSERVATIONAL

Enrollment

150

Conditions

Hyperuricemia

Interventions

Uric acid levelOTHER

Eligibility

Sex: ALLMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Patients must have at least one serum uric acid level l ≥ 7.0 mg/dL within the last two years without a clinical diagnosis of gout per American College of Rheumatology criteria30 (appendix A). 2. Patients, of matched gender and age, with normal uric acid levels will serve as controls. Exclusion Criteria: 1. Patients who meet or have met the ACR criteria for Gout, unable to read English, and/or have terminal illness will not be eligible to participate in the study. 2. Patients with a diagnosis of skin psoriasis31, rheumatoid arthritis, or spondyloarthropathies will not be eligible to participate. 3. Patients who are on urate-lowering therapy. 4. Patients with 1 or 2 total knee replacements.

Locations (2)

Howard University Hospital

Washington D.C., District of Columbia, United States

WashingtonVAMC

Washington D.C., District of Columbia, United States

Outcomes

Primary Outcomes

Number of Urate Depositions Detected in Ultrasound

Time frame: 2 years

Data from ClinicalTrials.gov

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