A randomized controlled trial comparing wake therapy (single night) followed by bright light therapy to treatment as usual.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
32
Eligible patients are assisted in maintaining total sleep deprivation during one night
Bright light according to patients´ own circadian rhythm each morning for a week.
All patients are admitted due to severe depression and are under observation and most receive antidepressive medication and if necessary anxiolytic/antipsychotic medication.
Sahlgrenska University Hospital
Gothenburg, Västra Götaland County, Sweden
MADRS-S score reduction of 50%
Montgomery Asberg Depression Rating Scale
Time frame: One week
MADRS-S score at discharge
Montgomery Asberg Depression Rating Scale
Time frame: Participants will be followed at discharge, an expected average of 2-3 weeks
MADRS-S score at follow-up
Montgomery Asberg Depression Rating Scale
Time frame: 10-14 weeks
ISI score score at discharge
Insomnia Severity Index - Self administered scale of sleep quality
Time frame: Participants will be followed at discharge, an expected average of 2-3 weeks
ISI score score at follow-up
Insomnia Severity Index - Self administered scale of sleep quality
Time frame: 10-14 weeks
ISI score reduction of 50%
Insomnia Severity Index - Self administered scale of sleep quality
Time frame: One week
Length of stay
Patients will be followed up 10-14 weeks after discharge and the total number of days in inpatient services calculated.
Time frame: The number of days between admission and discharge
Re-admission
Time frame: 10-14 weeks
CGI score
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A short sleep hygiene consultation.
Since all patients are admitted due to a severe mental illness, they will receive medication according to indication. Most patients have already tried more than one antidepressant at the time of admission. In cases of severe anxiety, anxiolytics are prescribed but this is kept to a minimum.
Clinical global impression
Time frame: One week
CGI score
Clinical global impression
Time frame: 10-14 weeks
Medication use
The use of antidepressants, anxiolytics or other psychiatric medication will be registered at follow-up. The number of patients using more than one medication and the dosage will be compared.
Time frame: 10-14 weeks