The Value of Diagnosis and Outcome Prediction in CTC for Metastatic NPC Patients

Sun Yat-sen University166 enrolled

Overview

A circulating tumor cell (CTC) count is an established prognostic factor in some malignancies such as metastatic breast cancer. However, the value of CTC in diagnosis and outcome prediction of metastatic nasopharyngeal carcinoma (mNPC) patients is not unknown. Through the observational prospective clinical trial, sensitivity, specificity, positive and negative predictive values of CTC in diagnosis of mNPC patients will be gained. Further, the value of CTC in outcome prediction of mNPC patients will be uncovered.

Study Type

OBSERVATIONAL

Enrollment

166

Conditions

Nasopharyngeal Neoplasms

Interventions

the number of circulating tumor cellsOTHER

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Histologically or radiologically confirmed nasopharyngeal non-keratinizing carcinoma (WHO II, III). * NPC patients with distant metastasis including synchronous distant metastasis at diagnosis and metachronous distant metastasis after radical treatment. * A Karnofsky performance status score more than 70. * The participants provided written informed consent. Exclusion Criteria: * A history of previous or synchronous malignant tumors. * Suffering from severe mental illness synchronously. * Suffering from severe heart or lung diseases. * Obvious abnormality in liver and renal function. * Women in pregnancy or breastfeeding.

Outcomes

Primary Outcomes

Overall survival rate

Time frame: 3 years

Secondary Outcomes

The proportion of positives that are correctly identified as such

number of true positives divided by (number of true positives plus number of false negatives)

Time frame: 3 years

The proportion of negatives that are correctly identified as such

number of true negatives divided by (number of true negatives plus number of false positives)

Time frame: 3 years

The proportions of positive results in statistics and diagnostic tests that are true positive results.

number of true positives divided by number of positive calls

Time frame: 3 years

The proportions of negative results in statistics and diagnostic tests that are true negative results.

number of true negatives divided by number of negative calls

Time frame: 3 years

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.