ARTEMIS Synovial Markers in Arthritis Childhood

University Hospital, Montpellier30 enrolled

Overview

The aim of this study is to find markers that could differentiate infectious and inflammatory arthritis. The investigators want to find markers by differential analysis by compare synovial fluids of septic and inflammatory arthritis. The investigators will use for this analysis, proteomics, cytokine dosage and monocyte typing by flow cytometry analysis. The investigators will use one marker or a score with biological and clinical data to discriminate arthritis of infectious and inflammatory etiology.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

DIAGNOSTIC

Masking

SINGLE

Enrollment

Conditions

Septic Arthritis Juvenile Idiopathic Arthritis

Interventions

Articular punction, salivary samples, blood samplePROCEDURE

Eligibility

Sex: ALLMin age: 6 MonthsMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Septic arthritis with bacteriological identification * Juvenile idiopathic arthritis beyond the ILAR definition * Having acute arthritis requiring an articular draining * Child benefiting from a national insurance scheme * Collection of the consent of the parents or the legal representative Exclusion Criteria: * Contraindication in an articular draining: platelet 50 000 / mm3, Rate of prothrombins lower than 70 %, activated partial thromboplastin times (APTT)\> 1,5 * Treatment by biotherapy, corticoids or other immuno suppressor in the month preceding the articular draining. * Treatment by antibiotic begun more than 24 hours before the draining.

Locations (1)

Hôpital Arnaud de Villeneuve

Montpellier, France

Outcomes

Primary Outcomes

Qualitative analysis of new biological markers (proteic, cytokine or cellular) that discriminate inflammatory and infectious arthritis.

Identify blood sampling biomarkers of Arthritis childhood

Time frame: 1 day

Data from ClinicalTrials.gov

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