Beta-blockers in Pulmonary Arterial Hypertension

Phase 2TerminatedNCT02507011

University of Minnesota2 enrolled

Overview

The investigators will conduct a, randomized, phase 2, placebo-controlled, double-blinded, crossover trial of carvedilol in 26 PAH patients with World Health Organization functional class II or III symptoms and RV ejection fraction (EF) \< 45% for 6 months.

Adult PAH patients on a stable dose of an approved PAH medication will undergo the following baseline assessments: cardiac magnetic resonance imaging (MRI), right heart catheterization (RHC), echocardiogram, 6-minute walk test (6-MWT), plasma NT-ProBNP (biomarkers of RV function) and serum catecholamine (measure of sympathetic activation), and quality of life. Patients will be randomized to carvedilol (3.125 mg bid and escalated to 9.375 mg bid, as tolerated, over 3 months) or placebo in a 1:1 fashion. After 6 months, testing is repeated and patients are crossed over to the alternate treatment. Testing is repeated at the end of the study (month 13).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pulmonary Arterial Hypertension

Interventions

CarvedilolDRUG

Beta-adrenergic receptor blocker

PlaceboDRUG

Placebo

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age \> 18 years * WHO category 1 pulmonary arterial hypertension (Nice 2013) * WHO functional class II-III * RVEF by cardiac MRI \< 45% * Stable on PAH-specific therapy as defined by no change in PAH-specific treatment and functional class in the past 3 months. Patient can be on either mono or combination PAH-specific therapy Exclusion Criteria: * Subjects will be excluded from participation in the study if any of the following conditions exist: * Significant persistent bradycardia (resting heart rate \< 60 bpm) without a permanent pacemaker * Second or third degree AV block without a permanent pacemaker * Significant sinus tachycardia (resting heart rate \> 110 bpm) * Use of anti-arrhythmic drugs * Hypotension defined as systolic blood pressure \< 100 mmHg at the time of enrollment * Significant illness in the past 30 days requiring hospitalization * Acute decompensated right heart failure within past 30 days * Known allergy or intolerance to carvedilol or other β blockers * Cardiac index \< 2 l/min/m2 or right atrial pressure \> 15 mm Hg by right heart catheterization within last 3 months * Asthma * Positive pregnancy test in patients of child bearing-potential

Locations (1)

University of Minnesota Medical Center

Minneapolis, Minnesota, United States

Outcomes

Primary Outcomes

Mean Change in Right Ventricular Ejection Fraction as Measured by Cardiac MRI

Time frame: 6 months

Data from ClinicalTrials.gov

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