Thiotepa-based Conditioning for Allogeneic Stem-cell Transplantation (SCT) in Lymphoid Malignancies

Inclusion Criteria: 1. Age less than physiologic 68 years. 2. Patients with MM, NHL, HL and CLL with an indication for allogeneic transplantation as follows: 1. MM; patients relapsing after autologous transplant or with high-risk cytogenetic abnormalities 2. Aggressive lymphoma and Hodgkin lymphoma; relapse after autologous transplants 3. Follicular lymphoma; failure of at least one prior regimen 4. CLL; failure of prior therapy which includes Fludarabine combinations or 17p- cytogenetic abnormality 3. Patients must have an HLA matched related or unrelated donor willing to donate either peripheral blood stem cells or bone marrow. Matching is based on high-resolution class I (HLA-A, -B, -C) and class II (HLA-DRB1, -DQB) typing. The goal is to transplant \> 3 x 106 CD34+ cells per kg body weight of the recipient 4. Patients must sign written informed consent. 5. Adequate birth control in fertile patients. Exclusion Criteria: 1. Bilirubin \> 3.0 mg/dl, transaminases \> 3 times upper normal limit 2. Creatinine \> 2.0 mg/dl 3. ECOG-Performance status \> 2 4. Uncontrolled infection 5. Pregnancy or lactation 6. Abnormal lung diffusion capacity (DLCO \< 40% predicted) 7. Severe cardiovascular disease 8. CNS disease involvement 9. Pleural effusion or ascites \> 1 liter 10. Known hypersensitivity to Fludarabine or treosulfan 11. Psychiatric conditions/disease that impair the ability to give informed consent or to adequately co-operate