Phase 1 Bioavailability Study of SYR-322MET

Inclusion Criteria: 1. In the opinion of the investigator, the participant is capable of understanding and complying with protocol requirements. 2. Signs and dates a written, informed consent form and any required privacy authorization prior to the initiation of any study procedures including requesting that a participant fast for any laboratory evaluations. 3. Is a healthy male or female. 4. Is aged 18 to 55 years, inclusive, at the time of informed consent and first study medication dose. 5. Weighs at least 50 kilogram (kg) and has a body mass index (BMI) from 18.5 to 30.0 kilogram per square meter (kg/m\^2), inclusive at Screening. 6. A male participant who is nonsterilized and sexually active with a female partner of childbearing potential agrees to use adequate contraception from signing of informed consent throughout the duration of the study and for 30 days after last dose. 7. A female participant of childbearing potential who is sexually active with a nonsterilized male partner agrees to use routinely adequate contraception from signing of informed consent and throughout the duration of the study and for 30 days after last dose. Exclusion Criteria 1. Has received any investigational compound within 30 days prior to Check-in (Day-1). 2. Has received alogliptin or metformin hydrochloride (HCl) in a previous clinical study or as a therapeutic agent within 90 days prior to Check-in (Day-1). 3. Is an immediate family member, study site employee, or is in a dependent relationship with a study site employee who is involved in the conduct of this study (example, spouse, parent, child, sibling) or may consent under duress. 4. Has clinically significant history or current diagnosis of cardiovascular, respiratory, neurological, endocrine, hematopoietic, immune, urinary, genital, gastrointestinal, hepatic and psychiatric diseases. 5. Has fasting blood glucose lower than 3.88 millimoles per liter (mmol/L) 6. Has experienced acute infectious diseases within 4 weeks before screening. 7. Has a history of clinically significant allergic reactions or has a known hypersensitivity to any component of the formulation of alogliptin, metformin or related compounds. 8. Has a positive urine drug result for drugs of abuse (defined as any illicit drug use) or positive alcohol breath test at Screening or Check-in (Day -1). 9. Consumes over 10 drinks weekly (1 drink is equivalent to 0.5 liters of beer, 200 milliliter \[mL\] of dry wine or 50 mL of hard liquor) or has a history of alcoholism, drug and/or substance abuse. 10. Has taken any excluded medication, supplements, or food products during the time periods listed in the Excluded Medications and Dietary Products table, including intake of medicines with pronounced effects on blood circulation, liver function (barbiturates, omeprazole, cimetidine, etc.) within 2 months before Day -1 of Period 1. 11. If female, the participant is pregnant or lactating or intending to become pregnant before, during, or within 30 days after participating in this study; or intending to donate ova during such time period. 12. If male, the participant intends to donate sperm during the course of this study or for 12 weeks after the last dose of study medication. 13. If female, the subject is having unprotected sex with non-sterilized men within 30 days before the IMP administration. 14. Has current or recent (within 6 months) gastrointestinal disease that would be expected to influence the absorption of drugs (that is, a history of malabsorption, esophageal reflux, peptic ulcer disease, erosive esophagitis, frequent \[more than once per week\] occurrence of heartburn, or any surgical intervention. 15. Has non-standard diet (example, vegetarian or vegan) or lifestyle (including nighttime work, extreme physical activity such as weights lifting), which may interfere with the trial. 16. Has a history of cancer, except basal cell carcinoma which has been in remission for at least 5 years prior to Day 1 of Period 1. 17. Has a positive test result for hepatitis B surface antigen (HBsAg), hepatitis C virus (HCV) antibody, human immunodeficiency virus (HIV) antibody or syphilis at screening. 18. Has used nicotine-containing products (including but not limited to cigarettes, pipes, cigars, chewing tobacco, nicotine patch or nicotine gum) within 28 days prior to Check-in Day -1. Cotinine test is positive at Screening or Check-in (Day 1). 19. Has poor peripheral venous access. 20. Has donated or lost 450 mL or more of his or her blood volume (including plasmapheresis), or had a transfusion of any blood product within 30 days prior to Day 1 of Period 1. 21. Has abnormalities in routine physician examination, laboratory and/or ECG findings 22. Has a systolic blood pressure greater (\>)130 millimeter of mercury (mm Hg) or less than (\<)100 mm Hg , diastolic blood pressure \>90 mm Hg or \<70 mm Hg; heart rate \<60 bpm or \>80 bpm at screening (Day -28 to Day -2) or check-in to Period 1 (Day -1). 23. Has participated in any clinical study within 3 months before Day -1 of Period 1.