Short-term Effects of Oxytocin Nasal Spray on Chronic Tinnitus

Berthold Langguth, MD, Ph.D.15 enrolled

Overview

The study compares the short-term tinnitus reduction following a single oxytocin intervention with a placebo control condition.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

QUADRUPLE

Enrollment

Conditions

Chronic Tinnitus

Interventions

SyntocinonDRUG

Oxytocin nasal spray

PlaceboDRUG

distilled water in nasal spray

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * chronic tinnitus with a duration \> 6 months * medical examination by an ENT specialist * sufficient knowledge of the Portuguese language to follow the instructions and answer the questionnaires * VAS score \>4 points Exclusion Criteria: * vascular tinnitus * muscular tinnitus * conductive hearing loss * previous experience with oxytocin nasal spray * additional medications during the intervention

Outcomes

Primary Outcomes

Change of tinnitus on VAS

Time frame: 30 minutes after intervention

Change of Clinical global impression scale

Time frame: 30 minutes after intervention

Secondary Outcomes

Audiometry measured in dB HL

measured in dB HL

Time frame: within one hour before intervention

Minimum Masking Level measured in dB HL

measured in dB HL

Time frame: within one hour before intervention

Tinnitus Matching

Frequency measured in Hz

Time frame: within one hour before intervention

Data from ClinicalTrials.gov

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