In order to examine the current endotracheal intubation practice among critically ill patients, a prospective observational multicenter study of adult critically ill patients was conducted from July 2015 to January 2017 involving 20 ICUs. In this study, the primary aim was to describe, through a prospective observational multicenter study, the current intubation practice of adult critically ill patients undergoing endotracheal intubations with a focus on deriving and validating a prediction model for both immediate airway and hemodynamic complications.
Aim 1: To derive and validate a prediction model for difficult airway (three or more attempts at laryngoscopy to place an endotracheal tube and/or the need for another operator among the critically ill) \[37\]. Aim 2: To derive and validate a prediction model for hemodynamic compromise, i.e., post-intubation hypotension \[defined as a decrease at any point in mean arterial pressure less than 65 mmHg; systolic blood pressure less than 80 mm Hg and/or a reduction in systolic blood pressure of 40% from baseline; or the initiation of, or increase in infusion dosage of, any vasopressor medication (bolus or infusion) during the 30 minute period following intubation\] \[38-39\]. Aim3: To derive and validate a predication model for hypoxemia (decrease in pulse oximetry to oxygen saturation less than 88% during the procedure).
Study Type
OBSERVATIONAL
Enrollment
1,288
Mayo Clinic, Scottsdale
Scottsdale, Arizona, United States
University of South California
Los Angeles, California, United States
Number of participants with Hypoxemia in the 30 minutes following intubation
Time frame: 30 minutes
Number of participants with hypotension in the 30 minutes following intubation
Time frame: 30 minutes
Number of participants with unanticipated difficult airway
defined by 3 or more attempts or two operators
Time frame: 10 minutes
Mechanical ventilation free days in-hospital
Time frame: 28 days or in-hospital
Total days of ICU/hospital length of stay
Time frame: 30 days or in-hospital
Number of participants with vital status (dead/alive)
Time frame: 30 days or in-hospital
Number of participants with disposition to home, nursing home or long term care facility
Time frame: 30 days or in-hospital
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
Memorial Medical Center
Modesto, California, United States
Bridgeport Hospital/Yale
Bridgeport, Connecticut, United States
Mayo Clinic, Jacksonville
Jacksonville, Florida, United States
University of Kentucky
Lexington, Kentucky, United States
Cynthia Callahan,Berkshire Medical Center
Pittsfield, Massachusetts, United States
Detroit Medical Center
Detroit, Michigan, United States
Mercy Hospital
St Louis, Missouri, United States
Creighton University
Omaha, Nebraska, United States
...and 6 more locations