Assessment of the evolution of fibrinogen plasma level within the first ten days after major trauma in order to determine prevalence of hyperfibrinogenemia (Fg \> 4 g/L) and its time to onset.
In this study, investigators daily investigate fibrinogen plasma levels and fibrinogen antigen in severe trauma patients (Injury severity score \> 15) within the first ten days. Investigators then modelize hyperfibrinogenemia profiles according to severity of injuries and physiopathologic mechanisms. Finally, investigators determine predisposing risk factors to develop hyperfibrinogenemia and assess the impact of fibrinogen replacement therapy in initial phase of management of major trauma.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
150
Investigators analyze hematological parameters with blood sampled daily in severe trauma patients
Department of Anesthesiology and critical care, Lapeyronie University Hospital
Montpellier, France
RECRUITINGdaily fibrinogen level >4 g/L
the occurrence and delay of fibrinogen level \> 4 g/L after major trauma
Time frame: 10 days
assessing predisposing risk factors of hyperfibrinogenemia (> 4 g/l)
Initial chock status severity, vascular filling, initial acidose, hypothermia, trauma severity (ISS scores, Sequential Organ Failure Assessment (SOFA), IGS2), numbers and sites of lesions (AIS scores), severity of initial failure of fibrinogene, administration of fibrinogene at initial hemorrhagic phase…
Time frame: 10 days
plasmatic fibrinogen level evolution
Time frame: 10 days
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