Effect of Nutrition and Lifestyles on Obesity and Chronic Disease in China

Chinese PLA General Hospital1,000 enrolled

Overview

This research is aimed at verifying the effects of diets with high protein and low glycemic index (GI) on weight management among overweight or obese Chinese adult. Additionally, the investigators intend to verify the effects of two new approaches, including food replacement and Internet-of-things (IOT) monitoring on weight control.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

1,000

Conditions

Obesity

Interventions

EducationBEHAVIORAL

Food replacementDIETARY_SUPPLEMENT

IOT monitoringBEHAVIORAL

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * Health adult, age:18-65，BMI（kg/m2）:27.0-40.0 Exclusion Criteria: * Patients under regular medical treatment for chronic diseases like diabetes, hypertension, gout and hyperuricemia. * The patients with chronic renal diseases or other diseases which impose restrictions on the intake of proteins. * Mental patients. * People who suffer from secondary obesity caused by endocrine, metabolic disorders or some central nervous system diseases. * People who are under medical or surgical weight-loss treatments in the past three months. * People whose weight fluctuations are not less than 5kg in the past two months； * People with food allergies. * Men or women who drink regularly over 25g or 15 g daily,respectively. * Pregnant women and women who prepare to be pregnant. * Lactating women

Locations (2)

Southwest Hospital

Chongqing, Chongqing Municipality, China

RECRUITING

Hangzhou PLA sanatorium

Hangzhou, Zhejiang, China

RECRUITING

Outcomes

Primary Outcomes

Composite changes of weight, waist circumference and BMI

the measure is a composite

Time frame: 3~5 years

Body composition change is measured by means of Bioelectrical Impedance Analysis (BIA) and CT scan

Time frame: 3~5 years

Dropout ratio during weight-loss period and maintenance period

Time frame: 3~5 years

Secondary Outcomes

Composite changes in cardiovascular health indicators such as blood pressure, blood glucose, and blood lipids

Time frame: 3~5 years

Composite changes in inflammatory markers, diet and physical activity level, Leptin and adiponectin, compliance of weight-loss and other indicators

Time frame: 3~5 years

Composite changes in diet-related behaviors such as satiety, food preferences, social support, appetite, healthy lifestyle and psychological aspects

Time frame: 3~5 years

Central Contacts

Yuan He, MD

CONTACT

+86-10-62115671 heyuan8506@126.com

Data from ClinicalTrials.gov

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