Pharmacokinetics and Pharmacodynamics of Caspofungin (Cancidas ®) and Drug Tolerance of Fungi to Patients With an Invasive Fungal Infection in the Intensive Care Unit

Inclusion Criteria: * Patient is admitted to ICU with APACHE-II score more than 15 * Subject is 18 years old and older on the day of the first dosing * Subject with evidence of proven or probable IFI defined by modified criteria of European Organization for Research and Treatment of Cancer(EORTC) Exclusion Criteria: * patient is known to be hypersensitive to caspofungin * patient's Child-Pugh score is more than 9 * patient is prone to discontinue treatment result from lack of cost * patient or their guardian refuse to sign a informed consent form * patient concurrently receiving efavirenz, nevirapine, rifampin, systemic dexamethasone, phenytoin, carbamazepine, phenobarbital, or cyclosporine and other agents have influence on PK parameters of caspofungin * patient is treated with caspofungin within 24 hours