Dexmedetomidine's Sedative Effect on Diabetic Patient
Dexmedetomidine is a high selective α2 agonist,its sedative and analgesia feature is acclaimed. The pathogenesis of type 2 diabetes mellitus is associated with α2 excessive adrenaline receptors expression. This study is to evaluate whether the use of dexmedetomidine is helpful to Diabetic Patient through its antisympathetic effect
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
120
During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Dexmedetomidine(D) group, patient will be given dexmedetomidine 1μg/Kg for 10 minutes In anesthesia maintenance, D group will be given dexmedetomidine 0.4μg/Kg.h until 40 minutes before the end of surgery
During anesthesia induction, all patients will be given propofol,fentanyl,vecuronium bromide.But before induction start in Placebo(P) group, patient will be given placebo for 10 minutes In anesthesia maintenance, D group will be given placebo until 40 minutes before the end of surgery
sedation level
Ramsay score and BIS will be recorded before medication,5 min after medication, medication ending, 5 and 10 min after medication
Time frame: from 5 minutes before medication to 10 minutes after Dexmedetomidine discontinuance，length of time frame is about 2 hours
Heart rate
recorded at before medication,5 min after medication, medication ending, 5 and 10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days
Mean arterial pressure
10 min after medication, before intubation, after intubation, after skin incision,60 minutes after skin incision, after extubation,first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days
blood glucose measured by Biochemical test
it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days
cortisol measured by Biochemical test
it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days
insulin measured by Biochemical test
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it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days
adrenaline measured by Biochemical test
it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days
noradrenaline measured by Biochemical test
it will be recorded immediately after the entrance to the operating room, before operation, 60 minutes after incision, after extubation, first day after operation
Time frame: participants will be followed from operation day to first postoperative day，an expected average of 2 days