Physiological Changes With SPG Stimulation in Migraine Patients

Danish Headache Center12 enrolled

Overview

Hypothesis: Stimulation of the SPG at low frequencies (20 Hz)is believed to cause a physiological parasympathetic upregulation which increases VMCA, concentration and cephalic vessel diameter.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Chronic Migraine

Interventions

NeurostimulationDEVICE

Neurostimulation of sphenopalatine ganglion (SPG) of 20 Hz

Sham stimulationDEVICE

Sham stimulation of sphenopalatine ganglion (SPG) with amplitude=0

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * Chronic migraine patients Exclusion Criteria: \-

Locations (1)

Danish Headache Center

Copenhagen, Glostrup, Denmark

Outcomes

Primary Outcomes

Changes of mean blood velocity of middle cerebral artery (VMCA) using transcranial Doppler upon low frequency SPG stimulation

Time frame: 0-90 min

Data from ClinicalTrials.gov

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