Comparison of Mechanical Penetration Enhancers on Metvixia Skin Penetration

Inclusion Criteria: * Male or female of non childbearing potential, who is at least 18 years of age or older at screening visit. * The subject has a skin phototype of I to III on Fitzpatrick's scale (Fitzpatrick et al., 1993) at screening visit. * Subject should have 9 mini zone areas on the back that will be able to receive pre-treatments according to protocol. (checked at Screening visit, and assigned at Baseline visit) * Female of non childbearing potential (postmenopausal \[absence of menstrual bleeding for 1 year prior to screening visit, without any other medical reason\], hysterectomy or bilateral oophorectomy). Exclusion Criteria: * Subject with porphyria, * Subject with past history of skin cancer, or current clinical diagnosis of other skin disease (including non-melanoma skin cancer), or tattoos, or cheloid and hypertrophic scars on the test zones, which, in the opinion of the investigator, might interfere with the interpretation of the clinical results, * Any uncontrolled or serious disease, or any medical or surgical condition, that may either interfere with the interpretation of the clinical trial results, and/or put the subject at significant risk (according to Investigator's judgment) if he/she participates in the clinical trial. * Known or suspected allergies or sensitivities to any components of any of the study drugs (see Product label). * The subject has received, applied or taken some specific treatments within specified time frame prior to the baseline visit