TBE (Tick-borne Encephalitis) Vaccination in Allergic Patients

Inclusion Criteria: * completed primary TBE immunization + at least one booster immunization * adults of both sexes between 18 and 60 years of age * willingness to sign written informed consent form Exclusion Criteria: * age \< 18 and \> 60 years * prior TBE infection * Hepatitis A vaccination * pregnancy and breast feeding * acute infection on day of inclusion (day 0), body temperature \>37,9°C * concomitant medications: systemic cortisone therapy, chemotherapy, immunosuppressive therapy 4 weeks prior to or during study * administration of other vaccines 4 weeks before/after TBE vaccination * planned surgery within 2 weeks before/after TBE vaccination * Start of de-sensitization and the first 4 weeks of allergen dose escalation * any contraindication to administration of FSME-Immun® vaccine according to manufacturer's instructions * history of malignant disease within the last 5 years * autoimmune diseases * drug addictions * plasma donors * receipt of blood transfusions or immuno globulins within 3 month before study entry