PET/MRI Imaging of Glutamate Release in the Brain

Phase 2TerminatedNCT02511691

University of Zurich10 enrolled

Overview

Based on PET (18-PSS232) and MRI, glutamate release after N-acetylcystein challenge will be monitored in human brains.

Diagnostic trial with quantification of glutamate release in PET/MR.

Study Type

INTERVENTIONAL

Allocation

Purpose

DIAGNOSTIC

Masking

NONE

Enrollment

Diagnostic PET Tracer

Sex: ALLMin age: 20 YearsMax age: 75 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * healthy volunteer Exclusion Criteria: * smoker * drug addiction * significant neurological or psychiatric conditions

University Hopsital Zurich

Zurich, Switzerland

Difference of Binding Potentials of 18F-PSS232 in different brain regions between Baseline PET and PET after medical challenge

for details, please see Innis: Journal of Cerebral Blood Flow \& Metabolism (2007) 27, 1533-1539

Time frame: Baseline PET and PET after medical challenge will be scanned within 3 months

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