Investigation of the Influence of Careless™, a Mangifera Indica Fruit Powder, on Microcirculation and Endothelial Function

Inclusion Criteria: * Subject is able and willing to sign the Informed Consent Form prior to screening evaluations * Subject is in good physical and mental health as established by medical history, physical examination, electrocardiogram, vital signs, results of biochemistry and haematology * Healthy normal skin condition at the forearm * BMI: 19-30 kg/m2 * Female * Age ≥ 40 and ≤ 70 years * Nonsmoker * Able and willing to follow the study protocol procedures Exclusion Criteria: * Relevant history, presence of any medical disorder or chronic intake of medication/dietary supplements (e.g. polyphenols, L-Arginine, Niacin, medication of haemodilution, blood flow stimulating products like Aspirin) potentially interfering with this study at screening * For this study clinically relevant abnormal laboratory, vital signs or physical findings at screening * Atopic dermatitis or affected skin at the forearm * Regular consumption of caffeine \> 275 mg (equivalent to 3-4 cups of coffee or 9 cups of black tea) * Change of dietary habits within the 2 weeks prior to screening (for instance start of a diet high in vegetables and fruits (≥ 5 portions per day)) * Diet high in vegetables and fruits ≥ 5 portions per day * Participants anticipating a change in their lifestyle or physical activity levels since this may also influence the results * Subjects not willing to avoid polyphenol rich foods and abstain from beverages containing caffeine the day prior to visit 1 and 2 * Subjects not willing to abstain from intake of analgesic medication (e.g. Aspirin) 24 hours prior to and during visit 1 and 2 * Sunbathing or the use of sun-beds 2 weeks prior to study days * Injury on the finger, influencing the EndoPAT™ measurement * Subjects with history of drug, alcohol or other substances abuse, or other factors limiting their ability to co-operate during the study * Known hypersensitivity to the study product or to single ingredients * Pregnant subject or subject planning to become pregnant during the study; breast-feeding subject. * Known HIV-infection * Known acute or chronic hepatitis B and C infection * Blood donation within 4 weeks prior to visit 1 or during the study * Subject involved in any clinical or food study within the preceding month