The study aims to determine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms.
Ionotropic glutamate receptors participate in pain in nervous system. In this study,participants will examine the expression of the ionotropic glutamate receptors in colon of irritable bowel syndrome (IBS) patients and evaluate the relationship between the ionotropic glutamate receptors and IBS symptoms. Participants may futher study the mechanism using cell experiment.
Study Type
OBSERVATIONAL
Enrollment
80
Patients will undergo colonoscopy and participants will get biopsies from the colon.
Department of Gastroenterology, Qilu Hospital, Shandong University
Jinan, Shandong, China
RECRUITINGthe expression of the ionotropic glutamate receptors
Participants will examine the expression level of ionotropic glutamate receptors using quantitative real-time RT-PCR and western blot ,examine the distribution using immunohistochemy.
Time frame: 4 months
the relationship between the ionotropic glutamate receptors and IBS symptom
Symptoms will be assessed though the severity of abdominal pain or discomfort and seizure frequency.Participants will evaluate the relationship between the expression level or the distribution of ionotropic glutamate receptors and IBS symptom. If there is a link between them, participants will study the underlying molecular mechanisms.
Time frame: 6 months
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