Comparison of Outcomes Between Parenteral and Enteral Nutrition

Tokyo University5,824 enrolled

Overview

Short-term outcomes of parenteral and enteral nutrition for patients unable to eat normally were compared and analyzed.

Data were acquired from patients selected from a national inpatient database covering 1,057 hospitals in Japan. Participants had received artificial nutrition between April 2012 and March 2013, were 20 years or older, and did not have cancer. Participants were grouped into two groups: those receiving parenteral nutrition and those receiving enteral nutrition. The investigators performed one-to-one propensity-score matching between the groups. The primary outcome measurements were mortality rates at 30 and 90 days after the start of the procedure. The secondary outcomes were post-procedural complications, pneumonia, and sepsis. The investigators analyzed survival length of stay after the procedure using a Cox proportional hazards model.

Study Type

OBSERVATIONAL

Enrollment

5,824

Conditions

Deglutition Disorders

Interventions

Parenteral nutritionDEVICE

Participants are retrospectively selected with propensity score matching

Enteral nutritionDEVICE

Participants are retrospectively selected with propensity score matching

Eligibility

Sex: ALLMin age: 20 Years

Medical Language ↔ Plain English

Inclusion Criteria: * investigators selected participants aged 20 years or older who had undergone either parenteral nutrition by central venous port insertion or enteral nutrition by percutaneous endoscopic gastrostomy, percutaneous transesophageal gastrotubing, or ileostomy between April 1, 2012, and March 31, 2013. Patients who received both gastrostomy and central venous port insertion were assigned to the gastrostomy group. Exclusion Criteria: * investigators excluded participants who had been diagnosed with cancer.

Outcomes

Primary Outcomes

Mortality Calculated From Outcome Section From DPC Database at 90 Days

Time frame: 90 days after the start of the procedure

Secondary Outcomes

Post-procedural Pneumonia

Time frame: the incidence of post-procedural pneumonia occurring during hospitalization. Participants will be followed for the duration of hospital stay, an expected median of 3 weeks after procedure.

Post-procedural Sepsis

Time frame: the incidence of post-procedural sepsis occurring during hospitalization. Participants will be followed for the duration of hospital stay, an expected median of 3 weeks after procedure.

Re-admission 30 Days

Time frame: re-admission within 30 days of discharge.

Mortality Calculated From Outcome Section From DPC Database at 14 Days

Time frame: 14 days after the start of the procedure

Mortality Calculated From Outcome Section From DPC Database at 30 Days

Time frame: 30 days after the start of the procedure

Data from ClinicalTrials.gov

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