Neoadjuvant SLOT Versus SOX in Patients With Locally Advanced, Resectable Gastric/Esophagogastric Junction (EGJ) Cancer

Inclusion Criteria: * Histologically proven gastric or GE junction adenocarcinoma; * Age: 18 to 70; * ECOG 0-2; * Adenocarcinoma of the stomach or GE junction according to staging classification TNM Scannographic: T3-4 N0/N + M0 ; * Completion of baseline quality of life questionnaire * Adequate bone marrow functions (ANC ≥ 1,500/ul, blood platelet ≥ 100,000/ul, haemoglobin ≥ 10g/dl); * Adequate renal functions(serum creatinine ≤ 1.5mg/dl) * liver functions (serum bilirubin ≤ 1.5UNL, AST/ALT ≤ 3 times(normal value) * Written informed consent Exclusion Criteria: * Previous chemotherapy; * Active infection requiring antibiotics * Pregnant, lactating women * Psychiatric illness, epileptic disorders * Concurrent systemic illness not appropriate for chemotherapy * History of other malignancy within 5 years except for non-melanoma skin cancer, cervix in situ carcinoma