Non Invasive Optical Imaging of WBC Count

Massachusetts General Hospital45 enrolled

Overview

This research study is looking at a small device that measures white blood cell (WBC) counts by being placed against the finger nail for participants who are undergoing stem cell transplantation at Massachusetts General Hospital or have a hematologic malignancy and are being seen as an outpatient.

The objective of this study is to obtain data that would support the use of a method to obtain WBC counts from images of small blood vessels called capillaries. These would be obtained by pressing a small device on the surface of participants' finger nails to look through the nail. These images will be obtained using a portable microscope called the Dino-Lite Digital Microscope. Having a non-invasive way to quickly measure WBC counts could be useful for a variety of healthcare applications.

Study Type

INTERVENTIONAL

Allocation

Purpose

DEVICE_FEASIBILITY

Masking

NONE

Enrollment

Conditions

Hematologic Malignancy

Interventions

AM4113-N5UT Dino-LiteDEVICE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with lymphoid malignancies or plasma cell dyscrasias who are admitted to the Massachusetts General Hospital to undergo autologous stem cell transplantation or are seen in the outpatient clinic * Age ≥ 18 years * Ability to understand and the willingness to sign a written informed consent document. * Patients must have WBC ≥ 3000 / µl and ANC ≥ 1500 / µl at admission or their last clinical visit to be enrolled. Exclusion Criteria: * History of allergic reactions attributed to compounds of similar chemical or biologic composition of baby oil. * Myelodysplasia * Skin phototype \< 4 in the Fitzpatrick scale.

Locations (1)

Massachusetts General Hospital

Boston, Massachusetts, United States

Outcomes

Primary Outcomes

Video of nail-fold imaging captured by capillaroscope

Image acquisition from device to then analyze and compare with complete blood counts measured in a standard fashion

Time frame: 4 weeks

Data from ClinicalTrials.gov

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