Follow-up of Patients Bound for PCI After Implementation of a Helicopter Emergency Medical System

Rigshospitalet, Denmark1,604 enrolled

Overview

This study compares patients bound for Percutaneous Coronary Intervention (PCI) who were transported by either ground ambulance or emergency medical helicopter. The investigators describe long-term follow-up in relation to mortality and labour affiliation.

Since 2003, percutaneous coronary intervention (PCI) for ST-Segment elevation myocardial infarction (STEMI) has been the preferred therapy in Denmark over fibrinolysis (thrombolysis) if performed within 120 minutes. Nevertheless, centralisation of designated PCI-centres may lead to systems delays as transport distance may be longer instead of just choosing thrombolysis at the nearest hospital. As every minute counts when trying to minimize the ischemic injury and size of infarction following an acute coronary event, timely transportation by helicopter may facilitate overall prognosis. As a part of a national initiative to improve prehospital care of patients with time critical illness such as myocardial infarction (MI), the first Danish Helicopter Emergency Medical System (HEMS) was implemented in the eastern part of Denmark May 1st 2010. An initial study on 450 patients investigating short-term effects, found that HEMS significantly reduced time from the first electrocardiogram (ECG) diagnosis on-scene to arrival at the cardiac catheterisation laboratory (CCL) despite longer transport distances. Investigators also found a lower, but insignificant 30-day mortality in HEMS patients, adjusted OR=0.40 (95% CI=0.12-1.39, p=0.14). The aim of the present study is to investigate long-term effects of HEMS in relation to mortality and labour market affiliation.

Study Type

OBSERVATIONAL

Enrollment

1,604

Conditions

ST-elevation Myocardial Infarction

Interventions

Helicopter Emergency Medical ServiceOTHER

May 1st 2010, the first Danish Helicopter Emergency Medical System (HEMS) was implemented in Region Zealand and the Capital Region of Denmark.

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * The investigators include all STEMI patients having acute coronary angiography performed at the PCI centre at Copenhagen University Hospital, Rigshospitalet in a 40-month period from January 1st 2010 until April 30th 2013; and who were diagnosed with STEMI within the geographical area covered by both HEMS and GEMS. Patients with multiple contacts; only first contact is eligible. Exclusion Criteria: * The investigators exclude patients with cardiac arrest before hospital admission. For labour market analyses the investigators exclude patients not working full time three weeks prior to admission.

Outcomes

Primary Outcomes

Short term mortality after admission to the PCI unit

Time frame: 30 day mortality

Secondary Outcomes

Long-term mortality after admission to the PCI unit.

Time frame: Mortality up to 5.5 years after admission to the PCI-unit

1-year mortality after admission to the PCI unit.

Time frame: 1-year mortality

Time to involuntary early retirement or death from any cause

Time frame: Up to 5.5 years after admission to the PCI unit

Reduced work ability two years after the coronary event (yes/no).

Time frame: Two years after admission to the PCI unit

Time on social transfer payments during the first two years after the coronary event

Time frame: Two years after admission to the PCI unit

Time to involuntary early retirement

Time frame: Up to 5.5 years after admission to the PCI unit

Data from ClinicalTrials.gov

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