Evaluating an innovative molecular imaging technique to visualize inflammation of the atherosclerotic plaque in patients with a recent ischemic stroke (\<15 days) with carotid stenosis\> 50%, by performing a Positron emission tomography-computed tomography (PET-CT) with PBR06 18F, a tracer for Translocator protein (TPSO).
More than one third of cerebral ischemic events are related to an atheromatous plaque. Inflammation, through a key player, the macrophage, is associated with increased metabolic activity of atherosclerotic plaque and its possible rupture. Inflammation within the plate is thus a marker of instability. These data underscore the importance of a prospective evaluation of inflammation with specific imaging with PET tracers inflammation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
3
Positron Emission Tomography / Computed Tomography (PET-CT) using 18F-PBR06
CHU de Bordeaux
Bordeaux, France
Correlation between the value of standardized uptake value (SUV) on PET-CT with 18F-PBR06 and the degree of macrophage infiltration at histological examination
Time frame: 15 days
Levels of leukocyte and T lymphocyte inflammation of the plaque
Evaluate the constitutive parameters of the plaque (surface area, thickness, necrotic core and fibrous cap)
Time frame: 15 days
Plaque parameters composite
Evaluate the constitutive parameters of the plaque (surface area, thickness, necrotic core and fibrous cap)
Time frame: 15 days
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