Prospective Trial of Autologous Platelet Rich Plasma in Aortic Surgery

Hongwen Ji80 enrolled

Overview

The purpose of this study is to determine whether autologous platelet rich plasma (APRP)is effective in reducing allogeneic blood transfusions during aortic surgery using deep hypothermic circulatory arrest.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

SINGLE

Enrollment

Conditions

C.Surgical Procedure; Cardiac

Interventions

Autologous Platelet-Rich Plasma Harvest TechniqueDEVICE

15 to 20 mL/kg of whole blood is collected before the administration of heparin from a large-bore central venous access,and is separated into red blood cells component and autologous platelet-rich plasma component by an autologous transfusion system(Sorin Group Electa Essential; Sorin Group Italia, Milan, Italy).

Eligibility

Sex: ALLMin age: 18 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: * patients undergoing elective or emergency aortic surgery using deep hypothermic circulatory arrest、 * preoperative platelet counts\>150000000000/L、 * preoperative hematocrit\>33%、 * without recent anticoagulants less than 5 days Exclusion Criteria: * preoperative coagulation disorder * severe renal and liver dysfunction * preoperative hemodynamic instability

Locations (1)

Cardiovascular Institute and Fuwai Hospital, CAMS&PUMC

Beijing, Beijing Municipality, China

Outcomes

Primary Outcomes

total perioperative allogenic transfusions of platelet and fresh frozen plasma

Time frame: on the 7th day postoperatively

Secondary Outcomes

postoperative blood loss

Time frame: on the 7th day postoperatively

rate of reexploration for bleeding

Time frame: on the 7th day postoperatively

Data from ClinicalTrials.gov

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