The diagnosis of sensory neuronopathy is difficult to establish because the only certainty criterion is based on the detection of specific lesions in the posterior spinal ganglion which is usually not possible. There is to date no clinical and electrophysiological criteria or validated biomarker for the diagnosis of this type of neuropathy. In a retrospective study, we analyzed the files of patients with peripheral sensory neuronopathy certain and established clinical and electrophysiological diagnostic criteria for sensitive neuronopathy. We therefore wish now validate these criteria and investigate possible associated antibodies on a prospective cohort of patients.
All the patients (patient group and control) will be included in the study after giving their consent. The clinical, biological and electrophysiological data concerning the neuropathy will be collected. There is no specific follow-up for the study. Blood samples will be retrospectively analyzed for antibody screening.
Study Type
OBSERVATIONAL
Enrollment
80
Neurological assessment (physical examination, electroneuromyography , International Prognostic Score (ISS), Overall Disability Scale (ODS)) and 2 blood collection tubes for antibody screening
CHU Angers
Angers, France
CHU Clermont-Ferrand
Clermont-Ferrand, France
CHU de Grenoble
Grenoble, France
Hospices Civils de Lyon
Lyon, France
AP-HM
Marseille, France
CHU de Montpellier
Montpellier, France
CHU de Nimes
Nîmes, France
Hopital Pitie Salpetriere
Paris, France
CHU Poitiers
Poitiers, France
Chu Saint-Etienne
Saint-Etienne, France
...and 2 more locations
Likelihood ratio diagnostic criteria established on the study population
The set of diagnostic criteria giving the best sensitivity and specificity for a diagnosis of sensory neuronopathy (composite measure)
Time frame: baseline
Identified antibodies
Sensibility and specificity of identified antibodies (composite measure)
Time frame: baseline
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