Circulating Tumor Cells in Operative Blood in Patients With Bladder Cancer

Inclusion Criteria: * Must meet all inclusion and exclusion criteria * Presence of a muscle invasive bladder tumor(s) (T2), specific for transitional cell carcinoma on pre-operative histology (i.e. biopsy or trans-urethral resection of bladder tumor \[TURBT\]) * Presence of a single bladder tumor lesion * Patients are scheduled to undergo ORC at our institution * Subjects must have given written informed consent to agree to participate * Previous chemotherapy, and/or biological therapy for cancer are permitted provided that the acoustic properties of the tumor were not affected, but the subject should have recovered from the effects of these or of any prior surgery * Subjects must be free of any clinically significant disease other than cancer that would interfere with the study evaluations * Absolute neutrophil count (ANC) \>= 1500 mm\^-3 * Platelet count \>= 100,000 mm\^-3 * Hemoglobin \>= 10 g/dl * Prothrombin time (PT) =\< 1.5 times upper limit of laboratory normal (ULN) * Activated partial thromboplastin time =\< 1.5 times ULN * Total bilirubin \< 1.5 times ULN * Aspartate aminotransferase (AST) =\< 3 times ULN * Alkaline phosphatase \< 2 times ULN, unless arising from bone Exclusion Criteria: * Subjects deemed unsuitable candidates and not medically optimized for ORC * Subjects with tumors lying \< 1 cm from sensitive structures such as the ureter, prostate or adjacent bowel * Patients with presence of multiple bladder lesions * Patients with pre-operative histologic confirmation of a bladder lesion other than transitional cell carcinoma * Subjects on concurrent anticoagulant, or immunosuppressive medication * Subjects on anti-cancer medication whether biologic or pharmaceutical * Women who are pregnant or nursing (pregnancy test to be performed within 24 hours prior to high intensity frequency ultrasound \[HIFU\] treatment) * Subjects assessed by consultant anesthetist as unsuitable for general anesthetic * Absolute Contraindications: venous injury at the level of the femoral veins or proximally; known or suspected thrombosis of the femoral or iliac veins on the proposed side of venous annulation, ambulatory patient * Relative Contraindications: presence of bleeding disorders; distortion of anatomy due to local injury or deformity; previous long-term venous catheterization; history of vasculitis; previous injection of sclerosis agents; previous radiation therapy