LEO 32731 - A Phase I Study in Healthy Subjects

Inclusion Criteria: * 1\. Subjects will, prior to any study related activities, have given their written informed consent to participate in the study and to abide by the study restrictions. * 2\. Subjects will be males or females of non-childbearing potential between 18 and 55 years of age. * 3\. Subjects will have a body mass index (BMI) between 18.0 and 30.0 kg/m2 inclusive. * 4\. For Group C, subjects will be women of non-childbearing potential. * 5\. Subjects must be in good health. Exclusion Criteria: * 1\. Male subjects who are not willing, or whose partners are not willing, to use appropriate contraception. * 2\. Subjects who have received any prescribed systemic or topical medication within 14 days of the first dose administration unless in the opinion of the Investigator the medication will not interfere with the study procedures or compromise safety. * 3\. Subjects who have used any non-prescribed systemic or topical medication (including herbal remedies) within 7 days of the first dose administration unless in the opinion of the Investigator the medication will not interfere with the study procedures or compromise safety. * 4\. Subjects who have received any medications, including St John's Wort (or other dietary restriction, Section 6.2.3), known to chronically alter drug absorption or elimination processes within 30 days of the first dose administration unless in the opinion of the Investigator the medication will not interfere with the study procedures or compromise safety. * 5\. Subjects with a significant history of drug allergy as determined by the Investigator. * 6\. Subjects who have any clinically significant allergic disease (excluding non-active hayfever) as determined by the Investigator. * 7\. Subjects who have a supine blood pressure and supine pulse rate at screening higher than 140/90 mmHg and 100 beats per minute (bpm), respectively, or lower than 90/50 mmHg and 50 bpm, respectively. * 8\. Subjects with a positive urine drug screen or alcohol breath test result at screening or first admission. * 9\. Subjects with, or with a history of, any clinically significant neurological, gastrointestinal, renal, hepatic, cardiovascular, psychiatric, respiratory, metabolic, endocrine, haematological, dermatological or other major disorders as determined by the Investigator. * 10\. Subjects who have had a clinically significant illness within 4 weeks of the start of dose administration as determined by the Investigator. * 11\. Subjects who are known to have serum hepatitis, or who are carriers of the hepatitis B surface antigen (HBsAg) or hepatitis C antibody, or who have a positive result to the test for HIV antibodies. * 12\. Active tuberculosis or history of incompletely treated tuberculosis, based on medical history or medical report. * 13\. Subjects who, in the opinion of their General Practitioner (GP) or the Investigator, should not participate in the study. * 14\. Subjects with one or more positive faecal occult blood test (immunochemical method) out of 2 assessments at the time between screening and Day-1 check-in. * 15\. Subjects with ≥ 3 bowel movements/day. * 16\. Subjects who have previously taken part in or withdrawn from this study. * 17\. Subjects who, in the opinion of the Investigator, should not participate in the study.