Comparison of Single and Repeated Dose of Vaginal Misoprostol for the Treatment of Early Pregnancy Failure

Wolfson Medical Center180 enrolled

Overview

A randomised controlled trial assessing the efficacy of single versus repeated dose of vaginal misoprostol for the treatment of early pregnancy failure.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

180

Conditions

Abortion, Missed

Interventions

MisoprostolDRUG

Eligibility

Sex: FEMALEMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women with early pregnancy failure, defined as missed abortion or blighted ovum, seeking medical treatment with misoprostol. * Age equal or greater than 18 years * Gestational age less than 12 complete weeks. Exclusion Criteria: * Complete, incomplete, inevitable, or septic abortion. * Hemodynamically unstable patients. * Misoprostol sensitivity or contraindication. * Multifetal pregnancies.

Locations (1)

Wolfson Medical Center

Holon, Israel

Outcomes

Primary Outcomes

Complete abortion (Endometrial thickness of less than 15 mm, as assessed by trans-vaginal ultrasound.)

Endometrial thickness of less than 15 mm, as assessed by trans-vaginal ultrasound.

Time frame: Day 8 from first misoprostol dose

Data from ClinicalTrials.gov

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