Non-small cell lung cancer is characterized by aggressive growth and treatment resistance. New approaches include immunotherapeutic strategies but spontaneous immune responses against tumor antigens remain unclear. The aim of this study is to characterize localization and frequencies of spontaneously induced memory T cells specific for a panel of tumor-associated antigens in peripheral blood and bone marrow of non-small cell lung cancer patients.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
NONE
Enrollment
120
Division of Thoracic Surgery, Technical University of Munich, Munich, Germany
Munich, Germany
Frequencies of tumor-specific T cells
% of all T cells
Time frame: 2 weeks postoperative
Tumor-specific T cells location determined by Enzyme Linked Immuno Spot Assay (ELISPOT) analysis of peripheral blood and bone marrow samples from the same patient
location: peripheral versus bone marrow
Time frame: 2 weeks postoperative
Long-term survival
OS
Time frame: 5 years postoperative
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