Efficacy and Safety of MT-3995 in Patients With Diabetic Nephropathy

Inclusion Criteria: * Type 2 diabetes mellitus * Glycated hemoglobin(HbA1c) values (National Glycohemoglobin Standardization Program : NGSP) ≤10.5% * estimated glomerular filtration rate(eGFR) of ≥30 mL/min/1.73 m2 * The median UACR of the first morning void urine samples is ≥50 mg/g Cr and \<300 mg/g Cr * Stable blood pressure(diastolic blood pressure (DBP) \<100 mmHg and stable systolic blood pressure (SBP) \<160 mmHg) Exclusion Criteria: * Type 1 diabetes, diabetes resulting from pancreatic injury, or secondary forms of diabetes. * A diagnosis of non-diabetic renal disease. * A following serum potassium level. * eGFR of 30-59mL/min/1.73m2; serum potassium level of \<3.5 or \>4.7 mmol/L, * eGFR of ≥60mL/min/1.73m2: serum potassium level of \<3.5 or \>5.0 mmol/L * symptomatic and clinically significant hypotension(diastolic blood pressure(DBP)\<50mmHg and systolic blood pressure(SBP)\<110mmHg) * QT prolongation or torsades de pointes, or, a history or family history of QT prolongation or torsades de pointes * New York Heart Association (NYHA) Class III or IV heart failure